rs74315366
A SNP in the SDHB gene on chromosome 1. Its most notable genotype is A;G: Hereditary PGL/PCC Syndrome
- Gene
- SDHB
- Location
- Chr 117,033,078 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs74315366 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SDHB SNPs
- rs74315367C;GHereditary PGL/PCC SyndromeVery important
- rs74315368C;THereditary PGL/PCC SyndromeVery important
- rs74315369A;GHereditary PGL/PCC SyndromeVery important
- rs74315370C;GHereditary PGL/PCC SyndromeVery important
- rs74315371C;THereditary PGL/PCC SyndromeVery important
- rs74315372G;THereditary PGL/PCC SyndromeVery important
- rs138996609A;GHereditary PGL/PCC SyndromeVery important
- rs200245469A;GHereditary PGL/PCC SyndromeVery important
Notes
From SNPedia
Notes
The concentration of basic and acidic compounds in guinea-pig lung [proceedings]. The pressure rises: update on the genetics of phaeochromocytoma. A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas. The occurrence of SDHB gene mutations in pheochromocytoma. Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas. The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas.
Source and license
Adapted from rs74315366 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.