rs743554

A SNP in the GALK1 gene on chromosome 17. Its most notable genotype is G;G: normal

Gene
GALK1
Location
Chr 1775,758,167 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
14%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodnormalTypical · 0.081% of people
  2. A;GNot rated2x higher ER- breast cancer riskTypical · 0.017% of people
  3. A;ANot rated2x higher ER- breast cancer riskTypical · 0.02% of people

SNPedia records rs743554 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 81% A;G 17% A;A 2%
  • European ancestry (Utah)G;G 73% A;G 23% A;A 3%
  • Han Chinese (Beijing)G;G 95% A;G 5% A;A 0%
  • Japanese (Tokyo)G;G 98% A;G 2% A;A 0%
  • Yoruba (Nigeria)G;G 58% A;G 36% A;A 7%

Conditions, medicines and genes

Notes

From SNPedia

Notes

microRNA 749 Swedish incident breast cancer cases with detailed clinical data and up to 15 years of follow-up together with 1493 matched controls. The strongest association was between the rs743554(T) allele of the ITGB4 gene and estrogen receptor negative (ER-) tumors (odds ratio 2.09, CI: 1.19-3.67) and worse survival compared to the wild type genotype carriers (hazard ratio [HR] 2.11, CI: 1.21-3.68). The poor survival was significantly associated with the aggressive tumour characteristics: high grade, lymph node metastasis and high stage.

Source and license

Adapted from rs743554 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.