rs74799832

A SNP in the RET gene on chromosome 10. Its most notable genotype is C;T: Multiple Endocrine Neoplasia IIA

Gene
RET
Location
Chr 1043,121,968 (GRCh38)
Highest magnitude
5.1Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableBadMultiple Endocrine Neoplasia IIAVery important · 5.1
  2. T;TGoodcommon in clinvarTypical · 0.0

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other RET SNPs

All RET SNPs

Notes

From SNPedia

Show notes, about 130 words

The oxygen affinity of haemoglobin Tak, a variant with an elongated beta chain. Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.

Source and license

Adapted from rs74799832 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.