rs7538876

A SNP in the PADI6 gene on chromosome 1. Its most notable genotype is A;A: 1.28x increased Basal Cell Carcinoma risk.

Gene
PADI6
Location
Chr 117,395,867 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.28x increased Basal Cell Carcinoma risk.Worth knowing · 2.18% of people
  2. A;GNot ratedNormal risk of Basal Cell Carcinoma.Minor · 1.842% of people
  3. G;GGood0.78x decreased Basal Cell Carcinoma risk.Worth knowing · 2.050% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 8% A;G 42% G;G 50%
  • European ancestry (Utah)A;A 15% A;G 54% G;G 31%
  • Han Chinese (Beijing)A;A 4% A;G 33% G;G 63%
  • Japanese (Tokyo)A;A 0% A;G 25% G;G 75%
  • Yoruba (Nigeria)A;A 10% A;G 48% G;G 42%
  • African ancestry (Southwest US)A;A 11% A;G 39% G;G 51%
  • Chinese (Denver)A;A 3% A;G 28% G;G 70%
  • Gujarati IndianA;A 21% A;G 49% G;G 31%
  • Luhya (Kenya)A;A 3% A;G 54% G;G 44%
  • Mexican ancestry (Los Angeles)A;A 5% A;G 45% G;G 50%
  • Maasai (Kenya)A;A 6% A;G 40% G;G 54%
  • TuscanA;A 12% A;G 46% G;G 42%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 190 words

2 SNPs located in different regions of chromosome 1 are likely to be associated with increased risk for basal cell carcinoma (BCC), the most common form of skin cancer. *each A at rs7538876 yields a 1.28x increased risk of developing BCC (p = 4.4 x 10e-12) *each G at rs801114 also yields a 1.28x increased odds of developing BCC (p = 5.9 x 10e-12) *2.68x increased risk of BCC for homozygous carriers of both SNPs This study was based on an analysis of ~2,000 Icelandic and Eastern European skin cancer patients (as well as a large number of controls). The authors estimate that approximately 1.6% of all individuals of European ancestry are homozygous for both risk alleles, and thus that percentage of the population is at 2.68x higher risk for BCC compared to individuals who are rs7538876(G;G) and rs801114(T;T). See also:23andMe blog

A;A

Slightly higher risk of this kind of skin cancer. This is the most common kind of cancer in the United States. These skin cancers are less likely to metastasize than other skin cancers, but still need to be treated.

A;G

Normal risk for this kind of skin cancer.

G;G

Reduced risk of this kind of skin cancer.

Source and license

Adapted from rs7538876 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.