rs7539542

A SNP in the ADIPOR1 gene on chromosome 1. Its most notable genotype is C;C: 0.51x decreased breast cancer risk

Gene
ADIPOR1
Location
Chr 1202,940,846 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated0.51x decreased breast cancer riskTypical · 0.021% of people
  2. C;GNot rated0.59x decreased breast cancer riskTypical · 0.038% of people
  3. G;GNot ratednormalTypical · 0.041% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageC;C 21% C;G 38% G;G 41%
  • European ancestry (Utah)C;C 50% C;G 42% G;G 8%
  • Han Chinese (Beijing)C;C 12% C;G 38% G;G 50%
  • Japanese (Tokyo)C;C 2% C;G 33% G;G 65%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 160 words

A study of 733 breast cancer cases for 10 SNPs concluded that a rs7539542 genotype was associated with decreased risk (odds ratio 0.51, CI: 0.28-0.92). After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001). Adiponectin signaling status was assigned as follows: rs1501299(G,G) + rs2241766(T,T) = low signaler rs1501299(G,T) + rs2241766(T,T) = low signaler rs1501299(G,G) + rs2241766(G,T) = low signaler rs1501299(T,T) + rs2241766(T,T) = intermediate signaler rs1501299(G,T) + rs2241766(G,T) = intermediate signaler rs1501299(G,G) + rs2241766(G,G) = intermediate signaler rs1501299(G,T) + rs2241766(G,G) = high signaler rs1501299(T,T) + rs2241766(G,G) = high signaler rs1501299(T,T) + rs2241766(G,T) = high signaler

Source and license

Adapted from rs7539542 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.