rs7568369

A SNP in the KLF7 gene on chromosome 2. Its most notable genotype is G;T: 0.90x reduced risk of obesity

Gene
KLF7
Location
Chr 2207,166,591 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GNot ratednormalTypical · 0.0100% of people
  2. G;TMost notableGood0.90x reduced risk of obesityMinor · 1.10% of people
  3. T;TGood0.90x reduced risk of obesityMinor · 1.10% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 100% G;T 0% T;T 0%
  • European ancestry (Utah)G;G 100% G;T 0% T;T 0%
  • Han Chinese (Beijing)G;G 100% G;T 0% T;T 0%
  • Japanese (Tokyo)G;G 100% G;T 0% T;T 0%
  • Yoruba (Nigeria)G;G 100% G;T 0% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7568369, also known as -963C>A, is a SNP in the Kruppel-like factor 7 KLF7 gene. A study of 14,818 Danish individuals with obesity found that the rs7568369(T) allele reduced obesity risk (odds ratio 0.90, CI: 0.84-0.96, p=0.001) and in studies of quantitative traits (n=5,535), this allele was associated with decreased body mass index (p=0.002) and waist circumference (p=0.003).

Source and license

Adapted from rs7568369 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.