rs7577363

A SNP in the ALK gene on chromosome 2. Its most notable genotype is A;A: >1.37x risk

Gene
ALK
Location
Chr 229,653,477 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
8%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated>1.37x riskTypical · 0.02% of people
  2. A;GNot rated1.37x riskTypical · 0.016% of people
  3. C;CNot ratedNo summary available.Typical · 0.00% of people
  4. G;GGoodcommonTypical · 0.082% of people

On SNPedia: (A;A), (A;G), (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 2% A;G 16% C;C 0% G;G 82%
  • European ancestry (Utah)A;A 0% A;G 6% C;C 0% G;G 94%
  • Han Chinese (Beijing)A;A 0% A;G 0% C;C 0% G;G 100%
  • Japanese (Tokyo)A;A 0% A;G 0% C;C 0% G;G 100%
  • Yoruba (Nigeria)A;A 8% A;G 37% C;C 0% G;G 56%
  • African ancestry (Southwest US)A;A 2% A;G 21% C;C 0% G;G 77%
  • Chinese (Denver)A;A 0% A;G <1% C;C 0% G;G 99%
  • Gujarati IndianA;A 2% A;G 13% C;C 0% G;G 85%
  • Luhya (Kenya)A;A 6% A;G 48% C;C 0% G;G 46%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 2% C;C 0% G;G 98%
  • Maasai (Kenya)A;A 8% A;G 33% C;C 0% G;G 58%
  • TuscanA;A 0% A;G 11% C;C 0% G;G 89%

Conditions, medicines and genes

Other ALK SNPs

All ALK SNPs

Notes

From SNPedia

Notes

rs7577363 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with this allele is 1.37 (CI 1.17-1.61).

Source and license

Adapted from rs7577363 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.