rs760805

A SNP in the LOC107984932 gene on chromosome 1. Its most notable genotype is A;A: 2x increased risk for bladder cancer

Gene
LOC107984932
Location
Chr 124,925,432 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
42%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x increased risk for bladder cancerTypical · 0.040% of people
  2. A;TNot ratedincreased risk for bladder cancer if part of risk haplotypeTypical · 0.038% of people
  3. T;TNot ratednormalTypical · 0.022% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 40% A;T 38% T;T 22%
  • European ancestry (Utah)A;A 19% A;T 44% T;T 38%
  • Han Chinese (Beijing)A;A 21% A;T 50% T;T 29%
  • Japanese (Tokyo)A;A 23% A;T 56% T;T 21%
  • Yoruba (Nigeria)A;A 98% A;T 2% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 130 words

rs760805, a SNP in the RUNX3 gene, has been reported to be the most significantly associated with risk for bladder cancer of several SNPs in this gene, based on a study of 368 Chinese patients. The adjusted odds ratio for the rs760805(A;A) genotype is 1.97 (CI: 1.44-2.69). Further investigation of this region in this same study indicated that 4 other SNPs in the RUNX3 gene, as well as smoking, are associated with increased risk for bladder cancer. In particular, 2 haplotypes, both containing the rs760805(A) allele, were associated with 2-3x increased risk. An individual carrying the risk forms of all 5 RUNX3 SNPs and also smoking had on average an odds ratio for bladder cancer that was 6.37 fold higher than average (CI: 4.57-8.87, p = 7.03 x 10(-28)).

Source and license

Adapted from rs760805 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.