rs7646054

A SNP in the ARHGEF3 gene on chromosome 3. Its most notable genotype is A;A: normal

Gene
ARHGEF3
Location
Chr 356,775,600 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.013% of people
  2. A;GBadincreased osteoporosis riskTypical · 0.037% of people
  3. G;GBadincreased osteoporosis riskTypical · 0.050% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 13% A;G 37% G;G 50%
  • European ancestry (Utah)A;A 27% A;G 38% G;G 35%
  • Han Chinese (Beijing)A;A 5% A;G 29% G;G 67%
  • Japanese (Tokyo)A;A 3% A;G 19% G;G 79%
  • Yoruba (Nigeria)A;A 4% A;G 36% G;G 60%
  • African ancestry (Southwest US)A;A 11% A;G 51% G;G 39%
  • Chinese (Denver)A;A 5% A;G 38% G;G 57%
  • Gujarati IndianA;A 21% A;G 42% G;G 37%
  • Luhya (Kenya)A;A 8% A;G 39% G;G 53%
  • Mexican ancestry (Los Angeles)A;A 29% A;G 36% G;G 35%
  • Maasai (Kenya)A;A 15% A;G 44% G;G 41%
  • TuscanA;A 12% A;G 40% G;G 48%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7646054 is a SNP in the ARHGEF3 gene. A study of 769 Australian female siblings found that the rs7646054(G) allele was significantly associated with lower bone mineral density (BMD) and thus osteoporosis in an age-related manner. Significant associations with hip and spine BMD were confirmed (p = 0.003-0.038), as well as an association with fracture rate (p = 0.02).

Source and license

Adapted from rs7646054 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.