rs767603

A SNP in the LOC105378189 gene on chromosome 14. Its most notable genotype is C;C: 0.63x reduced risk for intracranial aneurysm

Gene
LOC105378189
Location
Chr 1460,631,965 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated0.63x reduced risk for intracranial aneurysmTypical · 0.067% of people
  2. C;TNot ratednormalTypical · 0.028% of people
  3. T;TNot ratednormalTypical · 0.05% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 67% C;T 28% T;T 5%
  • European ancestry (Utah)C;C 82% C;T 15% T;T 3%
  • Han Chinese (Beijing)C;C 67% C;T 33% T;T 0%
  • Japanese (Tokyo)C;C 80% C;T 16% T;T 5%
  • Yoruba (Nigeria)C;C 40% C;T 49% T;T 11%

Notes

From SNPedia

Notes

A small study involving 29 Japanese patients with intracranial aneurysm felt it replicated the association of the rs767603(T) allele as being associated with higher risk in a dominant model. The odds ratio reported for rs767603(C;C) was 0.63 (CI: 0.45-0.89, p = 0.0076).

Source and license

Adapted from rs767603 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.