rs7683365

A SNP in the GYPB gene on chromosome 4. Its most notable genotype is A;A: MNS blood group S/S status predicted

Gene
GYPB
Location
Chr 4143,999,443 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodMNS blood group S/S status predictedMinor · 1.017% of people
  2. A;GGoodMNS blood group S/s status predictedMinor · 1.056% of people
  3. G;GGoodMNS blood group s/s status predictedMinor · 1.027% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in one HapMap population.

  • European ancestry (Utah)A;A 17% A;G 56% G;G 27%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7683365 is a polymorphism primarily determining the S>s antigen status for the MNS blood group. See more discussion on the GYPB gene page. The clinical significance of most common MNS blood group antigens is minimal. However, there are reports that while GYPB*S/S and GYPB*S/s individuals have average susceptibility to being infected with malaria, GYPB*s/s individuals are less susceptible to infection.

A;A

This genotype predicts a person with MNS blood group S/S antigen status.

A;G

The genotype predicts a person with MNS blood group S/s status.

G;G

This genotype predicts a person with MNS blood group s/s status.

Source and license

Adapted from rs7683365 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.