rs7753394

A SNP on chromosome 6. Its most notable genotype is C;C: 1.5x risk of Crohn's disease

Gene
None listed
Location
Chr 6137,764,111 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.5x risk of Crohn's diseaseTypical · 0.026% of people
  2. C;TBad1.2x risk of Crohn's diseaseTypical · 0.044% of people
  3. T;TNot ratednormalTypical · 0.030% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 26% C;T 44% T;T 30%
  • European ancestry (Utah)C;C 24% C;T 55% T;T 21%
  • Han Chinese (Beijing)C;C 2% C;T 29% T;T 69%
  • Japanese (Tokyo)C;C 6% C;T 20% T;T 74%
  • Yoruba (Nigeria)C;C 34% C;T 47% T;T 19%
  • African ancestry (Southwest US)C;C 30% C;T 54% T;T 16%
  • Chinese (Denver)C;C 5% C;T 37% T;T 58%
  • Gujarati IndianC;C 48% C;T 47% T;T 6%
  • Luhya (Kenya)C;C 40% C;T 46% T;T 14%
  • Mexican ancestry (Los Angeles)C;C 40% C;T 41% T;T 19%
  • Maasai (Kenya)C;C 31% C;T 58% T;T 12%
  • TuscanC;C 23% C;T 49% T;T 28%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7753394 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.21 (CI 1.04-1.40), and for homozygotes, 1.48 (CI 1.25-1.76).

Source and license

Adapted from rs7753394 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.