rs7771980

A SNP in the RUNX2 gene on chromosome 6. Its most notable genotype is C;C: lower bone mineral density in postmenopausal Korean women

Gene
RUNX2
Location
Chr 645,421,552 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedlower bone mineral density in postmenopausal Korean womenMinor · 1.00% of people
  2. C;TNot ratedhigher bone mineral density in postmenopausal Spanish womenMinor · 1.019% of people
  3. T;TNot ratednormalTypical · 0.081% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 0% C;T 19% T;T 81%
  • European ancestry (Utah)C;C 0% C;T 19% T;T 81%
  • Han Chinese (Beijing)C;C 0% C;T 24% T;T 76%
  • Japanese (Tokyo)C;C 0% C;T 30% T;T 71%
  • Yoruba (Nigeria)C;C 0% C;T 2% T;T 98%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 120 words

rs7771980, also known as -1025T>C, is a SNP in the RUNX2 gene, which encodes an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification. This SNP has been reported to be significantly associated with bone mineral density (BMD; and thus osteoporosis in several studies, but with different correlations. In a study of 821 Spanish postmenopausal women, rs7771980(C;T) women had higher mean adjusted femoral neck bone BMD values than those bearing the (T;T) genotype. In a study of 729 postmenopausal Korean women, the significant association found was that (C;C) women showed a significant association with reduced lumbar spine BMD and proximal femur sites compared with (C;T) or (T;T) subjects.

Source and license

Adapted from rs7771980 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.