rs7774434

A SNP on chromosome 6. Its most notable genotype is C;C: Increased risk of developing primary biliary cirrhosis

Gene
None listed
Location
Chr 632,689,801 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadIncreased risk of developing primary biliary cirrhosisWorth knowing · 2.018% of people
  2. C;TBadSlightly increased risk of developing primary biliary cirrhosisMinor · 1.549% of people
  3. T;TGoodNormal risk of developing primary biliary cirrhosisMinor · 1.033% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 18% C;T 49% T;T 33%
  • European ancestry (Utah)C;C 18% C;T 52% T;T 31%
  • Han Chinese (Beijing)C;C 15% C;T 50% T;T 35%
  • Japanese (Tokyo)C;C 26% C;T 53% T;T 21%
  • Yoruba (Nigeria)C;C 17% C;T 39% T;T 43%
  • African ancestry (Southwest US)C;C 16% C;T 47% T;T 37%
  • Chinese (Denver)C;C 8% C;T 53% T;T 38%
  • Gujarati IndianC;C 25% C;T 53% T;T 22%
  • Luhya (Kenya)C;C 16% C;T 45% T;T 39%
  • Mexican ancestry (Los Angeles)C;C 24% C;T 57% T;T 19%
  • Maasai (Kenya)C;C 16% C;T 43% T;T 41%
  • TuscanC;C 14% C;T 46% T;T 40%

Notes

From SNPedia

Notes

On the association between rheumatoid arthritis and classical HLA class I and class II alleles predicted from single-nucleotide polymorphism data. A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.

Source and license

Adapted from rs7774434 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.