rs7775228
A SNP in the HLA-DQB1 gene on chromosome 6. Its most notable genotype is T;T.
- Gene
- HLA-DQB1
- Location
- Chr 632,690,302 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 20%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 65%
- European ancestry (Utah)T;T 78%
- Han Chinese (Beijing)T;T 55%
- Japanese (Tokyo)T;T 42%
- Yoruba (Nigeria)T;T 63%
- African ancestry (Southwest US)T;T 72%
- Chinese (Denver)T;T 61%
- Gujarati IndianT;T 54%
- Luhya (Kenya)T;T 76%
- Mexican ancestry (Los Angeles)T;T 69%
- Maasai (Kenya)T;T 74%
- TuscanT;T 68%
Related
Conditions, medicines and genes
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs7775228 is one of three HLA region SNPs used to tag the DQ2.2 haplotype in gs221. rs7775228(T) was found to be associated with increased risk for osteoarthritis among Japanese, but not Europeans, with an odds ratio of 1.34 (CI: 1.21-1.49, combined p = 2.43×10e?8). This SNP is also in linkage disequilibrium with rs10947262, which was found to be associated in multiple populations with osteoarthritis. 23andMe reports that the C allele at rs7775228 is associated with hay fever (allergic rhinitis and allergy to grass pollen. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
Source and license
Adapted from rs7775228 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.