rs7807268
A SNP on chromosome 7. Its most notable genotype is C;C: 1.4x risk for Crohn's disease
- Gene
- None listed
- Location
- Chr 7148,560,956 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 49%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBad1.4x risk for Crohn's disease
- C;GBad1.3x risk for Crohn's disease
- G;GNot ratednormal
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 25% C;G 45% G;G 30%
- European ancestry (Utah)C;C 31% C;G 48% G;G 21%
- Han Chinese (Beijing)C;C 15% C;G 53% G;G 31%
- Japanese (Tokyo)C;C 11% C;G 41% G;G 49%
- Yoruba (Nigeria)C;C 21% C;G 45% G;G 34%
- African ancestry (Southwest US)C;C 26% C;G 35% G;G 39%
- Chinese (Denver)C;C 18% C;G 48% G;G 34%
- Gujarati IndianC;C 21% C;G 47% G;G 33%
- Luhya (Kenya)C;C 39% C;G 45% G;G 16%
- Mexican ancestry (Los Angeles)C;C 22% C;G 41% G;G 36%
- Maasai (Kenya)C;C 42% C;G 46% G;G 13%
- TuscanC;C 30% C;G 45% G;G 25%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs7807268 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.38 (CI 1.20-1.60), and for homozygotes, 1.47 (CI 1.24-1.74). * Note: there is a slight amount of ambiguity over the orientation of this SNP information relative to the dbSNP entry.
Source and license
Adapted from rs7807268 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.