rs7837688

A SNP on chromosome 8. Its most notable genotype is G;T: 1.7x increased risk for prostate cancer

Gene
None listed
Location
Chr 8127,527,115 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodNormalTypical · 0.082% of people
  2. G;TMost notableBad1.7x increased risk for prostate cancerWorth knowing · 2.117% of people
  3. T;TBad1.7x increased risk for prostate cancerWorth knowing · 2.12% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 82% G;T 17% T;T 2%
  • European ancestry (Utah)G;G 85% G;T 14% T;T <1%
  • Han Chinese (Beijing)G;G 71% G;T 26% T;T 3%
  • Japanese (Tokyo)G;G 69% G;T 28% T;T 4%
  • Yoruba (Nigeria)G;G 88% G;T 12% T;T <1%
  • African ancestry (Southwest US)G;G 95% G;T 5% T;T 0%
  • Chinese (Denver)G;G 76% G;T 19% T;T 5%
  • Gujarati IndianG;G 73% G;T 24% T;T 3%
  • Luhya (Kenya)G;G 83% G;T 17% T;T <1%
  • Mexican ancestry (Los Angeles)G;G 88% G;T 12% T;T 0%
  • Maasai (Kenya)G;G 85% G;T 14% T;T <1%
  • TuscanG;G 85% G;T 14% T;T 1%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7837688 is one of 4 tightly linked SNPs in the "locus 1" region of 8q24 chromosomal region, which has been linked in several studies to prostate cancer, initially through rs1447295. In a study of 1,563 patients of European ancestry, the odds ratio for prostate cancer associated with risk genotypes of locus 1 were reported as 1.70 (CI: 1.39-2.07). Two other regions of chromosome 8q24 were also studied.

Source and license

Adapted from rs7837688 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.