rs795484

A SNP in the TAOK3 gene on chromosome 12. Its most notable genotype is T;T: Even more increased morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomy

Gene
TAOK3
Location
Chr 12118,152,057 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadEven more increased morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomyWorth knowing · 2.59% of people
  2. C;TBadIncreased morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomyWorth knowing · 2.142% of people
  3. C;CGoodNormal morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomyMinor · 1.149% of people

SNPedia records rs795484 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 9% C;T 42% C;C 49%
  • European ancestry (Utah)T;T 9% C;T 46% C;C 46%
  • Han Chinese (Beijing)T;T 8% C;T 41% C;C 51%
  • Japanese (Tokyo)T;T 15% C;T 52% C;C 33%
  • Yoruba (Nigeria)T;T 8% C;T 41% C;C 51%
  • African ancestry (Southwest US)T;T 11% C;T 32% C;C 58%
  • Chinese (Denver)T;T 5% C;T 44% C;C 51%
  • Gujarati IndianT;T 6% C;T 33% C;C 61%
  • Luhya (Kenya)T;T 6% C;T 35% C;C 59%
  • Mexican ancestry (Los Angeles)T;T 7% C;T 43% C;C 50%
  • Maasai (Kenya)T;T 9% C;T 47% C;C 44%
  • TuscanT;T 16% C;T 45% C;C 39%

Notes

From SNPedia

Notes

Each minor allele at rs795484 (guanine [G]>adenine [A]) contributed +17.6 μg/kg (95% confidence interval [CI] 10.7-24.4) to dose. Effect direction and magnitude were replicated in an independent cohort of 75 EC children (P A) in the EC cohort (odds ratio 2.35, 95% CI 1.56-3.52, P<0.00005) and this association replicated in AA children (odds ratio 1.76, 95% CI 1.14-2.71, P<0.01).

Source and license

Adapted from rs795484 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.