rs7961152

A SNP in the LOC105369699 gene on chromosome 12. Its most notable genotype is A;A: 1.5x higher risk for hypertension

Gene
LOC105369699
Location
Chr 1224,828,677 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.5x higher risk for hypertensionWorth knowing · 2.011% of people
  2. A;CBad1.2x higher risk for hypertensionWorth knowing · 2.036% of people
  3. C;CNot ratednormalTypical · 0.053% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 11% A;C 36% C;C 53%
  • European ancestry (Utah)A;A 23% A;C 47% C;C 30%
  • Han Chinese (Beijing)A;A 2% A;C 23% C;C 75%
  • Japanese (Tokyo)A;A 4% A;C 17% C;C 80%
  • Yoruba (Nigeria)A;A 7% A;C 38% C;C 56%
  • African ancestry (Southwest US)A;A 14% A;C 37% C;C 49%
  • Chinese (Denver)A;A 4% A;C 28% C;C 69%
  • Gujarati IndianA;A 4% A;C 51% C;C 46%
  • Luhya (Kenya)A;A 7% A;C 45% C;C 48%
  • Mexican ancestry (Los Angeles)A;A 16% A;C 29% C;C 55%
  • Maasai (Kenya)A;A 17% A;C 41% C;C 42%
  • TuscanA;A 20% A;C 46% C;C 35%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7961152 has been reported in a large study to be associated with high blood pressure. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.16 (CI 1.01-1.32), and for homozygotes, 1.47 (CI 1.25-1.74). This SNP was just about the only one tested to replicate as associated with hypertension in a study of 7,551 Koreans patients, with an odds ratio of 1.28 (CI: 1.012-1.636, p=0.04) but only in one of two cohorts.

Source and license

Adapted from rs7961152 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.