rs7966230
A SNP in the VWF gene on chromosome 12. Its most notable genotype is G;G: slightly lower levels of plasma VWF
- Gene
- VWF
- Location
- Chr 126,126,464 (GRCh38)
- Highest magnitude
- 2.4Worth knowing
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;GBadslightly lower levels of plasma VWF
- G;GMost notableBadslightly lower levels of plasma VWF
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other VWF SNPs
- rs41276738T;TVon Willebrand disease, type 1Very important
- rs61748477A;AVon Willebrand disease, type 2NVery important
- rs61748478C;CVon Willebrand disease, type 2NVery important
- rs61748497G;GVon Willebrand disease, type 2NVery important
- rs61750584G;GVon Willebrand disease, type 2AVery important
- rs61750595A;Alikely miscall in Ancestry V2.0 datasets; otherwise, Von Willebrand disease, type 3Very important
- rs61750612A;AVon Willebrand disease, type 3Very important
- rs61750630A;AVon Willebrand disease, type 3Very important
Notes
From SNPedia
Show notes, about 140 words
rs7966230, also known as -1793G/C, is a SNP in the VWF gene on chromosome 12. This SNP is reasonably polymorphic in many populations. It does show a significant association with plasma VWF levels, reportedly more marked in subjects who are more than 40 years of age. The variant is reported to be associated with somewhat lower plasma levels of VWF. Publications discussing this mutation's discovery usually refer to the strand sequenced, since this is a SNP found upstream of the gene in the promoter region. The gene is transcribed in minus direction (based on the GRCh37 assembly), and so on the minus strand, the more common allele is (G) and the variant is (C). However, dbSNP defines this SNP on the plus strand (as does SNPedia and 23andMe), so the more common allele for rs7966230 is reported here as (C) and the variant as (G).
Source and license
Adapted from rs7966230 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.