rs8003379

A SNP in the MTHFD1 gene on chromosome 14. Its most notable genotype is A;A: normal

Gene
MTHFD1
Location
Chr 1464,406,881 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.071% of people
  2. A;CBadNo summary available.Typical · 0.025% of people
  3. C;CBadNo summary available.Typical · 0.04% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 71% A;C 25% C;C 4%
  • European ancestry (Utah)A;A 60% A;C 32% C;C 8%
  • Han Chinese (Beijing)A;A 99% A;C 2% C;C 0%
  • Japanese (Tokyo)A;A 100% A;C 0% C;C 0%
  • Yoruba (Nigeria)A;A 53% A;C 40% C;C 7%
  • African ancestry (Southwest US)A;A 65% A;C 30% C;C 5%
  • Gujarati IndianA;A 60% A;C 34% C;C 6%
  • Luhya (Kenya)A;A 61% A;C 36% C;C 4%
  • Mexican ancestry (Los Angeles)A;A 81% A;C 17% C;C 2%
  • Maasai (Kenya)A;A 67% A;C 30% C;C 4%
  • TuscanA;A 60% A;C 32% C;C 8%

Conditions, medicines and genes

Other MTHFD1 SNPs

All MTHFD1 SNPs

Notes

From SNPedia

Notes

rs8003379 is reported to represent a risk factor for abdominal aortic aneurysm (AAA), with odds ratio of 0.41 (CI: 0.26-0.65).

Source and license

Adapted from rs8003379 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.