rs8031627
A SNP in the SMAD3 gene on chromosome 15. Its most notable genotype is G;G: common in clinvar
- Gene
- SMAD3
- Location
- Chr 1567,191,781 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 60%
- European ancestry (Utah)G;G 60%
- Han Chinese (Beijing)G;G 27%
- Japanese (Tokyo)G;G 35%
- Yoruba (Nigeria)G;G 94%
- African ancestry (Southwest US)G;G 84%
- Chinese (Denver)G;G 39%
- Gujarati IndianG;G 56%
- Luhya (Kenya)G;G 94%
- Mexican ancestry (Los Angeles)G;G 39%
- Maasai (Kenya)G;G 83%
- TuscanG;G 57%
Related
Other SMAD3 SNPs
- rs387906851C;TLoeys-Dietz SyndromeVery important
- rs387906852A;GLoeys-Dietz SyndromeVery important
- rs387906856G;TLoeys-Dietz SyndromeVery important
- rs587776880-;ATLoeys-Dietz SyndromeVery important
- rs587776881-;ALoeys-Dietz SyndromeVery important
- rs587776882-;GLoeys-Dietz SyndromeVery important
- rs730880215A;GLoeys-Dietz SyndromeVery important
- rs753486471A;CFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
Source and license
Adapted from rs8031627 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.