rs8034191

A SNP in the AGPHD1 gene on chromosome 15. Its most notable genotype is C;C: 1.80x lung cancer risk; decreased response to alcohol

Gene
AGPHD1
Location
Chr 1578,513,681 (GRCh38)
Highest magnitude
2.6Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.80x lung cancer risk; decreased response to alcoholWorth knowing · 2.65% of people
  2. C;TBad1.27x lung cancer riskWorth knowing · 2.527% of people
  3. T;TNot ratednormalTypical · 0.068% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 5% C;T 27% T;T 68%
  • European ancestry (Utah)C;C 18% C;T 47% T;T 35%
  • Han Chinese (Beijing)C;C 0% C;T 4% T;T 96%
  • Japanese (Tokyo)C;C 0% C;T 4% T;T 96%
  • Yoruba (Nigeria)C;C 0% C;T 22% T;T 78%
  • African ancestry (Southwest US)C;C 4% C;T 27% T;T 70%
  • Chinese (Denver)C;C 0% C;T 10% T;T 90%
  • Gujarati IndianC;C 6% C;T 33% T;T 61%
  • Luhya (Kenya)C;C 3% C;T 31% T;T 66%
  • Mexican ancestry (Los Angeles)C;C 5% C;T 33% T;T 62%
  • Maasai (Kenya)C;C 3% C;T 38% T;T 59%
  • TuscanC;C 18% C;T 50% T;T 32%

Other AGPHD1 SNPs

All AGPHD1 SNPs

Notes

From SNPedia

Notes

23andMe blog rs8034191(C;C) decreased response to alcohol rs8034191 increases susceptibility to Lung cancer 1.27 times for heterozygotes (CT) and 1.80 times for homozygotes (CC) rs8034191 increases susceptibility to Lung cancer 1.28 times for heterozygotes (CT) and 1.81 times for homozygotes (CC)

Source and license

Adapted from rs8034191 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.