rs80356708
A SNP in the GRHPR gene on chromosome 9. Its most notable genotype is -;-: Primary Hyperoxaluria
- Gene
- GRHPR
- Location
- Chr 937,424,864 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadPrimary Hyperoxaluria
- -;GBadcarrier of Primary Hyperoxaluria allele
- G;GGoodcommon in clinvar
On SNPedia: (-;-), (-;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs80356708, also known as 103delG, is a mutation in the glyoxylate reductase/hydroxypyruvate reductase GRHPR gene. Individuals with two defective copies of the GRHPR gene may develop Primary hyperoxaluria type 2. The rs80356708(-) allele is such a defective allele, primarily found in Northern Europeans and their descendents. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Molecular analysis of the glyoxylate reductase (GRHPR) gene and description of mutations underlying primary hyperoxaluria type 2.
Source and license
Adapted from rs80356708 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.