rs80358740(C;G)

Likely miscall in Ancestry data; otherwise, BRCA2 variant considered pathogenic for breast cancer

Magnitude
6.0Very important
Repute
Bad
On SNPedia
rs80358740(C;G)
Gene
BRCA2

Other genotypes of rs80358740

  1. A;CMost notableBadBRCA2 variant considered pathogenic for breast cancerVery important · 6.0
  2. C;CGoodcommon in clinvarTypical · 0.0

All about rs80358740

Notes

From SNPedia

See details at rs80358740; note though that Promethease statistics now indicate a >10x miscall (false positive) rate in Ancestry data and has also received reports from three users (one with 23andMe data and two with Ancestry data) indicating that this genotype was not confirmed when checked using a clinically validated test.

Source and license

Adapted from rs80358740(C;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.