rs8051542

A SNP in the TOX3 gene on chromosome 16. Its most notable genotype is C;C: common/normal

Gene
TOX3
Location
Chr 1652,500,255 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon/normalTypical · 0.048% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 48%
  • European ancestry (Utah)C;C 31%
  • Han Chinese (Beijing)C;C 67%
  • Japanese (Tokyo)C;C 58%
  • Yoruba (Nigeria)C;C 61%
  • African ancestry (Southwest US)C;C 49%
  • Chinese (Denver)C;C 67%
  • Gujarati IndianC;C 47%
  • Luhya (Kenya)C;C 38%
  • Mexican ancestry (Los Angeles)C;C 33%
  • Maasai (Kenya)C;C 40%
  • TuscanC;C 34%

Notes

From SNPedia

Show notes, about 170 words

Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases. Breast cancer susceptibility loci and mammographic density. Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists. Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases. Leveraging genetic variability across populations for the identification of causal variants. Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population. Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women. Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium.

Source and license

Adapted from rs8051542 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.