rs807701

A SNP in the DCDC2 gene on chromosome 6. Its most notable genotype is G;G: 2-5x increased dyslexia risk

Gene
DCDC2
Location
Chr 624,273,563 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
42%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBad2-5x increased dyslexia riskWorth knowing · 2.123% of people
  2. A;GBadSlightly increased dyslexia riskMinor · 1.540% of people
  3. A;AGoodNormal dyslexia riskMinor · 1.037% of people

SNPedia records rs807701 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 23% A;G 40% A;A 37%
  • European ancestry (Utah)G;G 3% A;G 55% A;A 42%
  • Han Chinese (Beijing)G;G 7% A;G 42% A;A 51%
  • Japanese (Tokyo)G;G 2% A;G 46% A;A 52%
  • Yoruba (Nigeria)G;G 81% A;G 18% A;A 2%

Conditions, medicines and genes

Other DCDC2 SNPs

All DCDC2 SNPs

Notes

From SNPedia

Show notes, about 150 words

Rs807701, a SNP in the DCDC2 gene, is in a region that crops up in several independent studies as likely to associated with dyslexia. The risk allele in the Caucasian populations studied is (C). One study reports that the odds ratio for rs807701 genotypes increases if calculated from subsets of more severely dyslexic individuals as compared to more heterogenous, larger groups of dyslexic individuals. The genotype relative risk (GRR) for rs807701(C;C) increased from 1.88 (95% CI 0.89-3.97; P=.058) for the larger group up to 5.04 (95% CI 1.35-18.88; P=.002) for the most severely affected group. Combined with another SNP marker in the DCDC2 gene, rs793862, the (haplotype) GRR also increased for the homozygous haplotype rs793862(A)-rs807701(C), from 4.11 (95% CI 2.77-6.08; P<.0001) for the larger group, up to 11.13 (95% CI 6.32-19.60; P<.0001) for the most severely affected group.

G;G

higher risk of dyslexia

Source and license

Adapted from rs807701 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.