rs8099917

A SNP on chromosome 19. Its most notable genotype is G;G: lower odds of responding to PEG-IFNalpha/RBV treatment

Gene
None listed
Location
Chr 1939,252,525 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadlower odds of responding to PEG-IFNalpha/RBV treatmentImportant · 3.02% of people
  2. G;TBadModerately lower odds of responding to PEG-IFNalpha/RBV treatmentWorth knowing · 2.022% of people
  3. T;TGoodcommonTypical · 0.076% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 2% G;T 22% T;T 76%
  • European ancestry (Utah)G;G 3% G;T 25% T;T 73%
  • Han Chinese (Beijing)G;G 0% G;T 12% T;T 88%
  • Japanese (Tokyo)G;G <1% G;T 20% T;T 79%
  • Yoruba (Nigeria)G;G <1% G;T 3% T;T 96%
  • African ancestry (Southwest US)G;G 0% G;T 19% T;T 81%
  • Chinese (Denver)G;G <1% G;T 11% T;T 88%
  • Gujarati IndianG;G 2% G;T 33% T;T 65%
  • Luhya (Kenya)G;G 0% G;T 12% T;T 88%
  • Mexican ancestry (Los Angeles)G;G 9% G;T 47% T;T 45%
  • Maasai (Kenya)G;G 1% G;T 20% T;T 79%
  • TuscanG;G 1% G;T 40% T;T 59%

Conditions, medicines and genes

Notes

From SNPedia

Notes

23andMe blog rs8099917(C) less likely to respond to Hepatitis C treatment. rs12979860(C;C) better able to become naturally Hepatitis C virus-free. rs12980275(A) usually corresponds to the rs12979860(C)

G;G

Substantially lower odds of responding to PEG-IFNalpha/RBV treatment for hepatitis C.

G;T

Moderately lower odds of responding to PEG-IFNalpha/RBV treatment for hepatitis C.

Source and license

Adapted from rs8099917 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.