rs8177374

A SNP in the TIRAP gene on chromosome 11. Its most notable genotype is T;T: resistance to several diseases

Gene
TIRAP
Location
Chr 11126,292,948 (GRCh38)
Highest magnitude
3.5Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
8%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadvery common, but it seems better to have the minor allele which is protective against several diseasesTypical · 0.086% of people
  2. C;TGoodresistance to several diseasesImportant · 3.013% of people
  3. T;TMost notableGoodresistance to several diseasesImportant · 3.5<1% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 86% C;T 13% T;T <1%
  • European ancestry (Utah)C;C 68% C;T 30% T;T 2%
  • Han Chinese (Beijing)C;C 96% C;T 4% T;T 0%
  • Japanese (Tokyo)C;C 96% C;T 5% T;T 0%
  • Yoruba (Nigeria)C;C 99% C;T <1% T;T 0%
  • African ancestry (Southwest US)C;C 91% C;T 9% T;T 0%
  • Chinese (Denver)C;C 95% C;T 6% T;T 0%
  • Gujarati IndianC;C 75% C;T 22% T;T 3%
  • Luhya (Kenya)C;C 98% C;T 2% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 76% C;T 24% T;T 0%
  • Maasai (Kenya)C;C 91% C;T 9% T;T 0%
  • TuscanC;C 65% C;T 29% T;T 6%

Conditions, medicines and genes

Other TIRAP SNPs

All TIRAP SNPs

Notes

From SNPedia

Notes

23andMe blog rs8177374(T) less susceptible to infection with malaria, tuberculosis, bacteremia and pneumococcal disease.

T;T

A beneficial mutation which provides resistance to several diseases such as invasive pneumococcal disease, bacteremia, malaria, and tuberculosis.

Source and license

Adapted from rs8177374 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.