rs875858

A SNP in the VAC14 gene on chromosome 16. Its most notable genotype is T;T: docetaxel sensitive?

Gene
VAC14
Location
Chr 1670,741,552 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.095% of people
  2. C;TBaddocetaxel sensitive?Important · 3.55% of people
  3. T;TMost notableBaddocetaxel sensitive?Very important · 4.00% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageC;C 95% C;T 5% T;T 0%
  • European ancestry (Utah)C;C 85% C;T 15% T;T 0%
  • Han Chinese (Beijing)C;C 100% C;T 0% T;T 0%
  • Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%
  • Gujarati IndianC;C 88% C;T 12% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 93% C;T 7% T;T 0%
  • Maasai (Kenya)C;C 99% C;T <1% T;T 0%
  • TuscanC;C 92% C;T 8% T;T 0%

Source and license

Adapted from rs875858 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.