rs9263726

A SNP in the PSORS1C1 gene on chromosome 6. Its most notable genotype is A;A: In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects

Gene
PSORS1C1
Location
Chr 631,138,722 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadIn Japanese populations, associated with HLA-B*5801 allele and allopurinol side effectsImportant · 3.02% of people
  2. A;GBadIn Japanese populations, associated with HLA-B*5801 allele and allopurinol side effectsImportant · 3.020% of people
  3. G;GGoodcommon/normalTypical · 0.078% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 2% A;G 20% G;G 78%
  • European ancestry (Utah)A;A 2% A;G 25% G;G 74%
  • Han Chinese (Beijing)A;A <1% A;G 13% G;G 86%
  • Japanese (Tokyo)A;A 0% A;G 3% G;G 97%
  • Yoruba (Nigeria)A;A 0% A;G 28% G;G 72%
  • African ancestry (Southwest US)A;A 2% A;G 16% G;G 83%
  • Chinese (Denver)A;A 0% A;G 10% G;G 90%
  • Gujarati IndianA;A 1% A;G 14% G;G 85%
  • Luhya (Kenya)A;A 5% A;G 28% G;G 67%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 19% G;G 81%
  • Maasai (Kenya)A;A 5% A;G 37% G;G 58%
  • TuscanA;A 6% A;G 24% G;G 71%

Conditions, medicines and genes

Other PSORS1C1 SNPs

All PSORS1C1 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

The minor allele of this SNP, rs9263726, is reported to 100% predictive of the presence of an HLA-B*58:01 allele, at least in Japanese populations, and therefore also of greatly increased risk for HLA-B*58:01 related susceptibilities. An example of such a susceptibility is the greatly (>50X) increased odds of developing severe side effects from taking allopurinol.

A;A

see discussion at rs9263726

A;G

see discussion at rs9263726

Source and license

Adapted from rs9263726 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.