rs9273363

A SNP in the HLA-DQB1-AS1 gene on chromosome 6. Its most notable genotype is C;C: Much lower 0.15x risk of Type 1 Diabetes.

Gene
HLA-DQB1-AS1
Location
Chr 632,658,495 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABadHigher risk of Type 1 Diabetes.Worth knowing · 2.012% of people
  2. A;CGoodLower 0.87x risk of Type 1 Diabetes.Worth knowing · 2.035% of people
  3. C;CMost notableGoodMuch lower 0.15x risk of Type 1 Diabetes.Worth knowing · 2.153% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 12% A;C 35% C;C 53%
  • European ancestry (Utah)A;A 14% A;C 37% C;C 49%
  • Han Chinese (Beijing)A;A 15% A;C 46% C;C 39%
  • Japanese (Tokyo)A;A 18% A;C 39% C;C 43%
  • Yoruba (Nigeria)A;A 0% A;C 19% C;C 81%

Other HLA-DQB1-AS1 SNPs

All HLA-DQB1-AS1 SNPs

Notes

From SNPedia

Show notes, about 280 words

This is one of the SNPs that 23andMe uses for Type 1 diabetes. According to 23andMe, this SNP changes your risk of Type 1 Diabetes. That is an autoimmune disease where your immune system attacks your own body's insulin producing cells in the pancreas, preventing your blood sugar from being able to enter cells that need energy. This has been verified for white people. 23andMe originally wanted to use rs9272346 instead, but it was deemed unreliable.

A;A

According to 23andMe, this SNP increases your risk of Type 1 Diabetes. Type 1 Diabetes is an autoimmune disease where your immune system attacks your own body's insulin producing cells in the pancreas, preventing your blood sugar from being able to enter cells that need energy. This has been verified for white people. 23andMe originally wanted to use rs9272346 instead, but it was deemed unreliable.

A;C

According to 23andMe, this SNP somewhat reduces your risk of Type 1 Diabetes. Type 1 Diabetes is an autoimmune disease where your immune system attacks your own body's insulin producing cells in the pancreas, preventing your blood sugar from being able to enter cells that need energy. This has been verified for white people. 23andMe originally wanted to use rs9272346 instead, but it was deemed unreliable.

C;C

According to 23andMe, this SNP greatly reduces your risk of Type 1 Diabetes. Type 1 Diabetes is an autoimmune disease where your immune system attacks your own body's insulin producing cells in the pancreas, preventing your blood sugar from being able to enter cells that need energy. This has been verified for white people. 23andMe originally wanted to use rs9272346 instead, but it was deemed unreliable.

Source and license

Adapted from rs9273363 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.