rs9275596

A SNP in the LOC100507686 gene on chromosome 6. Its most notable genotype is C;C: 3x increased risk for developing a peanut allergy, 0.54x risk of IgA Nephropathy in Chinese

Gene
LOC100507686
Location
Chr 632,713,854 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad3x increased risk for developing a peanut allergy, 0.54x risk of IgA Nephropathy in ChineseImportant · 3.07% of people
  2. C;TBad1.7x increased risk for developing a peanut allergy, 0.54x risk of IgA Nephropathy in ChineseMinor · 1.736% of people
  3. T;TGoodcommon/normalTypical · 0.057% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 7% C;T 36% T;T 57%
  • European ancestry (Utah)C;C 12% C;T 43% T;T 46%
  • Han Chinese (Beijing)C;C 4% C;T 28% T;T 68%
  • Japanese (Tokyo)C;C 4% C;T 23% T;T 73%
  • Yoruba (Nigeria)C;C 13% C;T 45% T;T 42%
  • African ancestry (Southwest US)C;C 9% C;T 39% T;T 53%
  • Chinese (Denver)C;C 0% C;T 23% T;T 77%
  • Gujarati IndianC;C 4% C;T 33% T;T 63%
  • Luhya (Kenya)C;C 14% C;T 46% T;T 41%
  • Mexican ancestry (Los Angeles)C;C 0% C;T 38% T;T 62%
  • Maasai (Kenya)C;C 8% C;T 49% T;T 42%
  • TuscanC;C 11% C;T 32% T;T 57%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 160 words

rs9275596 is a SNP located between the HLA-DQB1 and HLA-DQA2 genes on chromosome 6. A study of several thousand children and their parents, most with food allergies, concluded that two SNPs, rs7192 and rs9275596, are associated with increased susceptibility to developing a peanut allergy in populations of European ancestry. The odds ratio reported for rs9275596(C) were 1.7 (p=10e-10). Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis. Kidney Disease

C;C

In populations of European ancestry, having two copies of a rs9275596(C) allele is associated with 3x increased risk for developing a peanut allergy.

C;T

In populations of European ancestry, each copy of a rs9275596(C) allele is associated with 1.7x increased risk for developing a peanut allergy.

Source and license

Adapted from rs9275596 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.