rs9298506

A SNP in the RP1 gene on chromosome 8. Its most notable genotype is A;A: ~1.46x increased risk of aneurysm

Gene
RP1
Location
Chr 854,524,964 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad~1.46x increased risk of aneurysmTypical · 0.065% of people
  2. A;GBad~1.21x increased risk of aneurysmTypical · 0.032% of people
  3. G;GGoodNormal risk of aneurysmTypical · 0.04% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 65% A;G 32% G;G 4%
  • European ancestry (Utah)A;A 62% A;G 36% G;G 3%
  • Han Chinese (Beijing)A;A 63% A;G 32% G;G 5%
  • Japanese (Tokyo)A;A 61% A;G 32% G;G 7%
  • Yoruba (Nigeria)A;A 69% A;G 29% G;G 3%
  • African ancestry (Southwest US)A;A 74% A;G 25% G;G 2%
  • Chinese (Denver)A;A 66% A;G 30% G;G 4%
  • Gujarati IndianA;A 59% A;G 37% G;G 4%
  • Luhya (Kenya)A;A 51% A;G 44% G;G 6%
  • Mexican ancestry (Los Angeles)A;A 76% A;G 22% G;G 2%
  • Maasai (Kenya)A;A 53% A;G 44% G;G 3%
  • TuscanA;A 80% A;G 18% G;G 2%

Conditions, medicines and genes

Other RP1 SNPs

All RP1 SNPs

Notes

From SNPedia

Notes

A meta-analysis in 2013 for more than 116,000 individuals showed OR 1.21; 95% CI 1.15–1.27. - 2013 Based on a large study (~6,000 cases and 14,000 controls) of both European and Japanese populations, the rs9298506(A) allele has been associated with higher risk of aneurysm, with an odds ratio per allele of 1.28 (CI:1.20-1.38, p=1.0e-06). Brain Aneurysm

A;A

Per-allele OR 1.21; 95% CI 1.15–1.27. See PMC3716358 - 2013 Per-allele OR 1.28; 95% CI 1.20-1.38. See PMC2861730 - 2010

A;G

Per-allele OR 1.21; 95% CI 1.15–1.27. See PMC3716358 - 2013 Per-allele OR 1.28; 95% CI 1.20-1.38. See PMC2861730 - 2010

Source and license

Adapted from rs9298506 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.