rs9303277

A SNP in the IKZF3 gene on chromosome 17. Its most notable genotype is T;T: 1.46x Increased risk of developing primary biliary cirrhosis

Gene
IKZF3
Location
Chr 1739,820,216 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNormal risk of developing primary biliary cirrhosisMinor · 1.029% of people
  2. C;TBad1.46x Slightly increased risk of developing primary biliary cirrhosisMinor · 1.547% of people
  3. T;TMost notableBad1.46x Increased risk of developing primary biliary cirrhosisWorth knowing · 2.024% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 29% C;T 47% T;T 24%
  • European ancestry (Utah)C;C 20% C;T 57% T;T 23%
  • Han Chinese (Beijing)C;C 42% C;T 46% T;T 12%
  • Japanese (Tokyo)C;C 42% C;T 47% T;T 12%
  • Yoruba (Nigeria)C;C 19% C;T 48% T;T 33%
  • African ancestry (Southwest US)C;C 14% C;T 49% T;T 37%
  • Chinese (Denver)C;C 51% C;T 42% T;T 7%
  • Gujarati IndianC;C 41% C;T 43% T;T 17%
  • Luhya (Kenya)C;C 8% C;T 51% T;T 41%
  • Mexican ancestry (Los Angeles)C;C 38% C;T 43% T;T 19%
  • Maasai (Kenya)C;C 18% C;T 44% T;T 38%
  • TuscanC;C 26% C;T 51% T;T 24%

Source and license

Adapted from rs9303277 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.