rs931127

A SNP in the SIPA1 gene on chromosome 11. Its most notable genotype is A;A: 2.15x more likely positive lymph node

Gene
SIPA1
Location
Chr 1165,637,829 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2.15x more likely positive lymph nodeWorth knowing · 2.118% of people
  2. A;GNot ratedNo summary available.Typical · 0.047% of people
  3. G;GNot ratedmore favorableTypical · 0.035% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 18% A;G 47% G;G 35%
  • European ancestry (Utah)A;A 27% A;G 56% G;G 17%
  • Han Chinese (Beijing)A;A 23% A;G 51% G;G 26%
  • Japanese (Tokyo)A;A 15% A;G 51% G;G 34%
  • Yoruba (Nigeria)A;A 10% A;G 40% G;G 51%
  • African ancestry (Southwest US)A;A 21% A;G 46% G;G 33%
  • Chinese (Denver)A;A 25% A;G 45% G;G 30%
  • Gujarati IndianA;A 22% A;G 57% G;G 21%
  • Luhya (Kenya)A;A 10% A;G 44% G;G 46%
  • Mexican ancestry (Los Angeles)A;A 7% A;G 45% G;G 48%
  • Maasai (Kenya)A;A 10% A;G 30% G;G 60%
  • TuscanA;A 33% A;G 47% G;G 20%

Conditions, medicines and genes

Other SIPA1 SNPs

All SIPA1 SNPs

Notes

From SNPedia

Notes

PMID 16563182 This SNP in can have implications for prognosis in breast cancer. It is located 313 base pairs upstream of the 5'-untranslated region of SIPA1 and is considered to be within the promoter region of the gene. SIPA1 germline polymorphisms are associated with aggressive disease behavior(lymph node metastasis) in the cohort examined

A;A

Women with this genotype and diagnosed with breast cancer were 2.15 times more likely to have lymph nodes node metastasis

A;G

In women diagnosed with breast cancer, this genotype is less favorable. It is more associated with lymph node metastasis

References

Source and license

Adapted from rs931127 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.