rs9387522

A SNP in the MANEA gene on chromosome 6. Its most notable genotype is A;A: increased risk of cocaine induced paranoia.

Gene
MANEA
Location
Chr 695,607,059 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedincreased risk of cocaine induced paranoia.Typical · 0.051% of people
  2. A;CNot ratedincreased risk of cocaine induced paranoia.Typical · 0.039% of people
  3. C;CNot ratednormalTypical · 0.010% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 51% A;C 39% C;C 10%
  • European ancestry (Utah)A;A 35% A;C 43% C;C 23%
  • Han Chinese (Beijing)A;A 85% A;C 15% C;C 0%
  • Japanese (Tokyo)A;A 55% A;C 39% C;C 6%
  • Yoruba (Nigeria)A;A 49% A;C 40% C;C 12%
  • African ancestry (Southwest US)A;A 40% A;C 44% C;C 16%
  • Chinese (Denver)A;A 75% A;C 23% C;C 2%
  • Gujarati IndianA;A 58% A;C 36% C;C 6%
  • Luhya (Kenya)A;A 49% A;C 41% C;C 10%
  • Mexican ancestry (Los Angeles)A;A 28% A;C 59% C;C 14%
  • Maasai (Kenya)A;A 54% A;C 42% C;C 4%
  • TuscanA;A 37% A;C 51% C;C 13%

Notes

From SNPedia

Notes

The A allele for this SNP is associated with increased risk of cocaine induced paranoia. source: Association of Variants in MANEA With Cocaine-Related Behaviors Lindsay A. Farrer, PhD; et al. Arch Gen Psychiatry. 2009;66(3):267-274. 23andMe blog rs12333032(T) is equivalent on the 23andMe platform. Each T at rs12333032 corresponds to increased odds of cocaine-induced paranoia. The paper did not specify the magnitude of the increase.

Source and license

Adapted from rs9387522 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.