rs944289

A SNP on chromosome 14. Its most notable genotype is T;T: 1.69x increased thyroid cancer risk

Gene
None listed
Location
Chr 1436,180,040 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNo summary available.Typical · 0.044% of people
  2. C;TBad1.3x increased thyroid cancer riskWorth knowing · 2.139% of people
  3. T;TMost notableBad1.69x increased thyroid cancer riskWorth knowing · 2.217% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 44% C;T 39% T;T 17%
  • European ancestry (Utah)C;C 19% C;T 43% T;T 39%
  • Han Chinese (Beijing)C;C 29% C;T 52% T;T 19%
  • Japanese (Tokyo)C;C 36% C;T 49% T;T 15%
  • Yoruba (Nigeria)C;C 79% C;T 19% T;T 2%
  • African ancestry (Southwest US)C;C 65% C;T 33% T;T 2%
  • Chinese (Denver)C;C 28% C;T 55% T;T 17%
  • Gujarati IndianC;C 24% C;T 55% T;T 22%
  • Luhya (Kenya)C;C 76% C;T 20% T;T 4%
  • Mexican ancestry (Los Angeles)C;C 41% C;T 40% T;T 19%
  • Maasai (Kenya)C;C 66% C;T 30% T;T 4%
  • TuscanC;C 25% C;T 35% T;T 40%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

Each A at rs965513 increased the odds of thyroid cancer by 1.75 times. Each T at rs944289 increased the odds of thyroid cancer by 1.37 times. A genoset, Gs137, has also been created in SNPedia to represent the increased risk reported for carriers of both variants. See also: 23andMe blog

Source and license

Adapted from rs944289 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.