rs9739493

A SNP in the WSCD2 gene on chromosome 12. Its most notable genotype is C;C: higher risk for hypertension

Gene
WSCD2
Location
Chr 12108,250,412 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedhigher risk for hypertensionTypical · 0.038% of people
  2. C;TNot ratedhigher risk for hypertensionTypical · 0.041% of people
  3. T;TNot ratedaverageTypical · 0.022% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 38% C;T 41% T;T 22%
  • European ancestry (Utah)C;C 27% C;T 44% T;T 29%
  • Han Chinese (Beijing)C;C 18% C;T 46% T;T 37%
  • Japanese (Tokyo)C;C 22% C;T 48% T;T 30%
  • Yoruba (Nigeria)C;C 78% C;T 20% T;T 2%
  • African ancestry (Southwest US)C;C 68% C;T 30% T;T 2%
  • Chinese (Denver)C;C 19% C;T 48% T;T 33%
  • Gujarati IndianC;C 20% C;T 46% T;T 35%
  • Luhya (Kenya)C;C 65% C;T 29% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 19% C;T 52% T;T 29%
  • Maasai (Kenya)C;C 53% C;T 40% T;T 7%
  • TuscanC;C 25% C;T 46% T;T 29%

Notes

From SNPedia

Notes

rs9739493, a SNP in the KIAA0789 gene, was associated with risk for hypertension in a study involving 1,500+ Japanese patients. The odds ratio associated with the risk allele, rs9739493(T), was not directly reported. Note that another SNP in the KIAA0789 gene, rs3794260, was determined to be in a different linkage disequilibrium block, and is thus thought to be an independent risk factor for hypertension.

Source and license

Adapted from rs9739493 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.