rs9864422

A SNP in the COL6A4P1 gene on chromosome 3. Its most notable genotype is C;C: normal

Gene
COL6A4P1
Location
Chr 315,185,745 (GRCh38)
Highest magnitude
0.0Typical
Tested on
Not on consumer chips
Minor allele frequency
25%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormalTypical · 0.055% of people
  2. C;TNot rated1.45x increased osteoarthritis riskTypical · 0.038% of people
  3. T;TNot rated1.45x increased osteoarthritis riskTypical · 0.07% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 55% C;T 38% T;T 7%
  • European ancestry (Utah)C;C 72% C;T 26% T;T 3%
  • Han Chinese (Beijing)C;C 31% C;T 50% T;T 20%
  • Japanese (Tokyo)C;C 38% C;T 52% T;T 10%
  • Yoruba (Nigeria)C;C 70% C;T 26% T;T 4%
  • African ancestry (Southwest US)C;C 51% C;T 46% T;T 4%
  • Chinese (Denver)C;C 32% C;T 46% T;T 22%
  • Gujarati IndianC;C 45% C;T 48% T;T 7%
  • Luhya (Kenya)C;C 58% C;T 37% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 60% C;T 36% T;T 3%
  • Maasai (Kenya)C;C 70% C;T 28% T;T 3%
  • TuscanC;C 80% C;T 20% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs9864422 is one of several SNPs in the DVWA gene found to be associated with osteoarthritis based on a study of several Japanese patient populations. The allelic odds ratio is 1.45 (CI: 1.27-1.66, p = 3.4 x 10e-8) for the minor allele, which is the (T) allele (in dbSNP orientation).

Source and license

Adapted from rs9864422 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.