rs987525

A SNP on chromosome 8. Its most notable genotype is A;A: 6x increased risk for cleft lip

Gene
None listed
Location
Chr 8128,933,908 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
25%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad6x increased risk for cleft lipWorth knowing · 2.015% of people
  2. A;CBad2.5x increased risk for cleft lipMinor · 1.030% of people
  3. C;CGoodnormalTypical · 0.054% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 15% A;C 30% C;C 54%
  • European ancestry (Utah)A;A 3% A;C 39% C;C 58%
  • Han Chinese (Beijing)A;A 0% A;C 8% C;C 92%
  • Japanese (Tokyo)A;A <1% A;C 6% C;C 93%
  • Yoruba (Nigeria)A;A 47% A;C 39% C;C 14%
  • African ancestry (Southwest US)A;A 30% A;C 52% C;C 18%
  • Chinese (Denver)A;A 0% A;C 15% C;C 85%
  • Gujarati IndianA;A 5% A;C 36% C;C 59%
  • Luhya (Kenya)A;A 36% A;C 46% C;C 17%
  • Mexican ancestry (Los Angeles)A;A 5% A;C 17% C;C 78%
  • Maasai (Kenya)A;A 35% A;C 41% C;C 24%
  • TuscanA;A 4% A;C 35% C;C 61%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 180 words

A genome-wide association study involving 224 cases and 383 controls of Central European origin found that significant association between rs987525 and risk for nonsyndromic cleft lip with or without cleft palate (NSCL/P). The odds ratio for rs987525(A;G) individuals was 2.57 (CI: 2.02-3.26), and for rs987525(A;A), 6.05 (CI: 3.88-9.43). The calculated population attributable fraction for this marker is 0.41, suggesting that this study has identified a major genetic cause for NSCL/P. 23andMe blog article Associated with European Facial Appearance *rs7590268 *rs16903544 *rs987525 *rs9574565 *rs227731 *rs642961 *rs1258763 Family-based study shows heterogeneity of a susceptibility locus on chromosome 8q24 for nonsyndromic cleft lip and palate. Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population. Genetic determination of human facial morphology: links between cleft-lips and normal variation. Defining predictors of cleft lip and palate risk. Cleft Lip and Cleft Palate

Source and license

Adapted from rs987525 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.