rs9938025

A SNP in the PKD1L3 gene on chromosome 16. Its most notable genotype is A;A: Lower odds of dry earwax in Europeans.

Gene
PKD1L3
Location
Chr 1671,988,142 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedLower odds of dry earwax in Europeans.Worth knowing · 2.013% of people
  2. A;GNot ratedUnknown effectWorth knowing · 2.042% of people
  3. G;GNot ratedHigher odds of dry earwax in Europeans.Worth knowing · 2.045% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 13% A;G 42% G;G 45%
  • European ancestry (Utah)A;A 10% A;G 45% G;G 45%
  • Han Chinese (Beijing)A;A 8% A;G 39% G;G 53%
  • Japanese (Tokyo)A;A 11% A;G 38% G;G 51%
  • Yoruba (Nigeria)A;A 14% A;G 45% G;G 40%
  • African ancestry (Southwest US)A;A 14% A;G 37% G;G 49%
  • Chinese (Denver)A;A 9% A;G 45% G;G 46%
  • Gujarati IndianA;A 21% A;G 45% G;G 34%
  • Luhya (Kenya)A;A 10% A;G 48% G;G 42%
  • Mexican ancestry (Los Angeles)A;A 12% A;G 40% G;G 48%
  • Maasai (Kenya)A;A 3% A;G 48% G;G 49%
  • TuscanA;A 27% A;G 35% G;G 38%

Conditions, medicines and genes

Notes

From SNPedia

Notes

23andme reports that having two copies of an "A" at rs9938025 is associated with moderately lower odds of dry earwax and having two copies of a "G" is associated with moderately higher odds in their customers with European ancestry compared to those who have "AG". https://www.23andme.com/en-eu/about/factoids/

Source and license

Adapted from rs9938025 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.