rs9954153

A SNP on chromosome 18. Its most notable genotype is G;G: ~5x higher risk for Fuchs' dystrophy, a corneal disorder

Gene
None listed
Location
Chr 1855,871,026 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad~5x higher risk for Fuchs' dystrophy, a corneal disorderWorth knowing · 2.02% of people
  2. G;TBad~2.5x higher risk for Fuchs' dystrophy, a corneal disorderWorth knowing · 2.018% of people
  3. T;TGoodcommonTypical · 0.079% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageG;G 2% G;T 18% T;T 79%
  • European ancestry (Utah)G;G 4% G;T 26% T;T 71%
  • Han Chinese (Beijing)G;G 0% G;T <1% T;T 99%
  • Japanese (Tokyo)G;G 0% G;T 0% T;T 100%
  • Yoruba (Nigeria)G;G 5% G;T 23% T;T 72%
  • African ancestry (Southwest US)G;G 4% G;T 33% T;T 63%
  • Gujarati IndianG;G 2% G;T 19% T;T 79%
  • Luhya (Kenya)G;G <1% G;T 17% T;T 82%
  • Mexican ancestry (Los Angeles)G;G 3% G;T 12% T;T 85%
  • Maasai (Kenya)G;G 1% G;T 26% T;T 73%
  • TuscanG;G 2% G;T 28% T;T 71%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs9954153 is a SNP in the transcription factor 4 TCF4 gene. It is one of several TCF4 SNPs reported to be independently associated with Fuchs' dystrophy.

Source and license

Adapted from rs9954153 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.