rs997669

A SNP in the CCNE1 gene on chromosome 19. Its most notable genotype is C;C: Very slightly increased (1.18x) increased breast cancer risk

Gene
CCNE1
Location
Chr 1929,813,576 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon/normalTypical · 0.071% of people
  2. C;TNot rated?Typical · 0.025% of people
  3. C;CMost notableBadVery slightly increased (1.18x) increased breast cancer riskMinor · 1.14% of people

SNPedia records rs997669 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 71% C;T 25% C;C 4%
  • European ancestry (Utah)T;T 39% C;T 50% C;C 12%
  • Han Chinese (Beijing)T;T 81% C;T 19% C;C 0%
  • Japanese (Tokyo)T;T 85% C;T 14% C;C <1%
  • Yoruba (Nigeria)T;T 82% C;T 16% C;C 2%
  • African ancestry (Southwest US)T;T 84% C;T 14% C;C 2%
  • Chinese (Denver)T;T 84% C;T 16% C;C <1%
  • Gujarati IndianT;T 57% C;T 40% C;C 3%
  • Luhya (Kenya)T;T 75% C;T 24% C;C 2%
  • Mexican ancestry (Los Angeles)T;T 64% C;T 31% C;C 5%
  • Maasai (Kenya)T;T 86% C;T 13% C;C 1%
  • TuscanT;T 49% C;T 40% C;C 11%

Conditions, medicines and genes

Other CCNE1 SNPs

All CCNE1 SNPs

Notes

From SNPedia

Notes

rs997669 shows an association with breast cancer in a British study involving ~2300 patients. The odds ratio for the (G;G) vs (A;A) homozygotes is 1.18 (CI: 1.04-1.34, p=0.003).

Source and license

Adapted from rs997669 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.