rs999737

A SNP in the RAD51L1 gene on chromosome 14. Its most notable genotype is C;C: common on affy axiom data

Gene
RAD51L1
Location
Chr 1468,567,965 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon on affy axiom dataTypical · 0.084% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageC;C 84%
  • European ancestry (Utah)C;C 52%
  • Han Chinese (Beijing)C;C 99%
  • Japanese (Tokyo)C;C 100%
  • Yoruba (Nigeria)C;C 100%
  • African ancestry (Southwest US)C;C 97%
  • Gujarati IndianC;C 84%
  • Mexican ancestry (Los Angeles)C;C 64%
  • Maasai (Kenya)C;C 99%
  • TuscanC;C 60%

Conditions, medicines and genes

Notes

From SNPedia

Notes

NIH rs999737 is located near an interesting gene, RAD51L1, which is in a pathway previously implicated in breast cancer risk. The protein encoded by this gene interacts directly with those of other genes that are involved in DNA repair and in the exchange of material between strands of DNA. common variants at 14q24.1 might not be associated with the risk of breast cancer in the Chinese population. Rs999737 is not a risk allele for Chinese

Source and license

Adapted from rs999737 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.