i3002432

A SNP on chromosome 11. Its most notable genotype is A;A: 6.7x increased risk of venous thromboembolism

Gene
None listed
Location
Chr 1146,761,055 (GRCh38)
Highest magnitude
6.7Very important
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad6.7x increased risk of venous thromboembolismVery important · 6.7
  2. A;GBad2.8x increased risk of venous thromboembolismWorth knowing · 2.8
  3. G;GGoodNo summary available.Typical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 280 words

Risk of Placental Abruption and Venous Thromboembolism according to 23andMe The publicly-recognized name for this SNP is rs1799963. In a 2013 meta-analysis of 31 databases, the analysis of i3002432 (PT20210A or prothrombin or Factor 2) was based on 9,134 cases and 17,606 controls. The average AG variant risk for Venous Thromboembolism was 2.8, and risk was higher for younger subjects ((< 45 years old, OR: 3.19; ≥ 45 years old, OR: 2.57) and for women taking oral contraceptives (women not using OCs, OR: 2.73; women using OCs, OR: 5.58). Further analysis by outcome revealed that more the risk for Cerebral venous sinus thrombosis was highest at 4.4 (based on 303 cases and 2,723 controls), whereas for Venous thromboembolism OR was 3.0, and for Venous thrombosis (w\o pulmonary embolism) OR 2.6. The AA risk was 6.74, but since homozygotes are rare, the OR was based on only 28 subjects among cases and 4 controls. A larger risk was seen in rs6025 Factor V Leiden SNP variants. In addition to the literature associating the G20210A variant with thromboembolism in general, several studies have found that this variant significantly (2 - 20 fold) increases the risk for ischemic stroke (aka cerebral ischemia) in individuals with patent foramen ovale (PFO), or hole in the heart. It is estimated that PFO is present in ~25% of the (normal/healthy) population. and See many more references listed at its alias SNP page rs1799963 See the related SNP rs6025 for further discussion. Oral Contraceptives, HRT and Risk of VTE

A;A

increased risk of venous thromboembolism according to and 23andMe and this blog posting.

A;G

increased risk of venous thromboembolism according to and 23andMe and this blog posting.

References

Source and license

Adapted from i3002432 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.