Venous thromboembolism

28 SNPs linked to Venous thromboembolism across 17 genes, 15 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 28
Notable: 15Magnitude 2 or higher
Well documented: 19
Genes: 17

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs6025F5Very important
- T;T11.4x higher risk of thrombosisBad
- C;T3.5-4.4x risk of thrombosisBad
- C;Cnormal/common risk of thrombosisGood
rs1799963F2Very important
- A;A6.74x risk of thrombosis; 2-20x risk for cerebral stroke if PFO+Bad
- A;G2.8x risk of thrombosis; higher risk for cerebral stroke if PFO+Bad
- G;Gnormal/common risk of thrombosisGood
i3002432Very important
- A;A6.7x increased risk of venous thromboembolismBad
- A;G2.8x increased risk of venous thromboembolismBad
- G;GNo summary available.Good
rs121918472PROS1Very important
- G;GIncreased venous thromboembolism risk (> 6x)Bad
- A;GLikely miscall in Ancestry data; otherwise, increased risk (~6x) for venous thromboembolismBad
- A;Acommon in clinvarGood
rs138925964PROS1Very important
- C;Ccommon/normalGood
- C;T2-4x higher risk for venous thromboembolism (clots)Bad
- T;TClotting issues likely in infantsBad
rs7080536HABP2Important
- A;Asignificant increase (2 - 6x?) in risk possible for carotid stenosis, stroke and venous thromboembolismBad
- A;G~2x higher risk for carotid stenosis, venous thromboembolismBad
- G;Gcommon in clinvarGood
rs5361SELEWorth knowing
- T;Tnormal riskGood
- G;Tnormal riskNot rated
- G;G4x increased risk for recurrent venous thromboembolism.Bad
rs268LPLWorth knowing
- A;Acommon in clinvarGood
- A;G3X increased risk for venous thromboembolismBad
- G;G3X+ increased risk for venous thromboembolismBad
rs505922ABOWorth knowing
- C;Cblood type is not O, increased risk for some diseases.Bad
- C;T1.2x risk of pancreatic cancerBad
- T;Tblood type OGood
rs9923231VKORC1Worth knowing
- C;CnormalGood
- C;Treduced warfarin dose if treated for VTENot rated
- T;Treduced warfarin dose if treated for VTENot rated
rs662PON1Worth knowing
- T;T~2x higher risk of of coronary heart disease reported in some studies, but lower risk seen in other studiesBad
- C;T0.65x lower risk of ovarian cancer; higher risk of coronary heart disease in some studies; somewhat reduced PON catalytic efficiencyNot rated
- C;CMixed; conflicting results reported related to stroke and CADNot rated
rs9574PROCRTypical
- C;CEPCR H1 diplotype; reduced risk of VTE?Not rated
- C;GEPCR H1 haplotype; reduced risk of VTE?Not rated
- G;Gnormal risk for VTENot rated
rs867186PROCRTypical
- A;Anormal risk for VTENot rated
- A;GEPCR H3 haplotype; reduced or increased risk of VTE?Not rated
- G;GEPCR H3 diplotype; reduced or increased risk of VTE?Not rated
- T;TNo summary available.Not rated
rs1042714ADRB2Typical
- C;CnormalGood
- C;Gcomplex; see details for increased risksNot rated
- G;Gcomplex; see details for increased risksNot rated
rs1799864CCR2Typical
- A;ANo summary available.Good
- A;GNo summary available.Good
- G;Gcommon in clinvarGood
rs2288904SLC44A2Typical
- C;CNo summary available.Not rated
rs3025058MMP3Typical
- -;-5A/5A; higher MI risk?Not rated
- -;T5A/6ANot rated
- T;T6A/6A; higher CAD riskNot rated
rs6427196F5Typical
- C;Ccommon in clinvarGood
rs6809699P2RY12Typical
- A;Acommon in clinvarGood
- C;Ccommon on affy axiom dataGood
rs146922325PROCVery important
- C;Ccommon in clinvarGood
- C;TPartial protein-C deficiency; higher risk for blood clotting related issuesBad
- T;TComplete protein-C deficiency; severe thrombophiliaBad
rs121909547SERPINC1Very important
- G;Gcommon in clinvarGood
- A;GVenous thromboembolism association/riskBad
rs121909569SERPINC1Very important
- A;GVenous thromboembolism association/riskBad
- A;Acommon in clinvarGood
rs201381904SERPINC1Very important
- C;Ccommon/normalGood
- C;T10x higher venous thromboembolism riskBad

Genes

Genosets

Gs190Increased risk of VTE (venous thromboembolism)Important

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 5 SNPs

Source and license

Adapted from Venous thromboembolism on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.