rs146922325
A SNP in the PROC gene on chromosome 2. Its most notable genotype is T;T: Complete protein-C deficiency; severe thrombophilia
- Gene
- PROC
- Location
- Chr 2127,426,114 (GRCh38)
- Highest magnitude
- 8.0Very important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TBadPartial protein-C deficiency; higher risk for blood clotting related issues
- T;TMost notableBadComplete protein-C deficiency; severe thrombophilia
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other PROC SNPs
- rs121918141T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918142C;CComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918143T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918144T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918146A;AComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918147A;AComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918148C;CComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918149A;AComplete protein-C deficiency; severe thrombophiliaVery important
Notes
From SNPedia
Notes
aka c.565C>T, p.Arg189Trp, R189W The rs146922325(T) mutation may be the most frequent pathogenic variant associated with venous thromboembolism in East Asian (including Chinese) populations.
C;T
Likely to be a milder form. See links via main rs-page.
T;T
Possibly less severe form. See links via main rs-page.
Source and license
Adapted from rs146922325 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.