rs121918146
A SNP in the PROC gene on chromosome 2. Its most notable genotype is A;A: Complete protein-C deficiency; severe thrombophilia
- Gene
- PROC
- Location
- Chr 2127,428,485 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadComplete protein-C deficiency; severe thrombophilia
- A;GBadCarrier of a thrombophilia due to protein C deficiency mutation
- G;GGoodcommon in clinvar
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PROC SNPs
- rs121918141T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918142C;CComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918143T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918144T;TComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918147A;AComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918148C;CComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918149A;AComplete protein-C deficiency; severe thrombophiliaVery important
- rs121918150A;AComplete protein-C deficiency; severe thrombophiliaVery important
Notes
From SNPedia
Notes
aka c.925G>A (p.Ala309Thr) 23andMe name: i5003628
A;A
See links via main rs-page.
A;G
Recessive carriers may have variable expressivity.
Source and license
Adapted from rs121918146 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.