rs505922
A SNP in the ABO gene on chromosome 9. Its most notable genotype is C;C: blood type is not O, increased risk for some diseases.
- Gene
- ABO
- Location
- Chr 9133,273,813 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe
- Minor allele frequency
- 35%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadblood type is not O, increased risk for some diseases.
- C;TBad1.2x risk of pancreatic cancer
- T;TGoodblood type O
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 13% C;T 43% T;T 44%
- European ancestry (Utah)C;C 12% C;T 48% T;T 40%
- Han Chinese (Beijing)C;C 15% C;T 43% T;T 42%
- Japanese (Tokyo)C;C 16% C;T 52% T;T 32%
- Yoruba (Nigeria)C;C 10% C;T 44% T;T 46%
- African ancestry (Southwest US)C;C 12% C;T 42% T;T 46%
- Chinese (Denver)C;C 9% C;T 46% T;T 45%
- Gujarati IndianC;C 20% C;T 43% T;T 38%
- Luhya (Kenya)C;C 7% C;T 50% T;T 43%
- Mexican ancestry (Los Angeles)C;C 12% C;T 24% T;T 64%
- Maasai (Kenya)C;C 9% C;T 43% T;T 48%
- TuscanC;C 20% C;T 34% T;T 46%
Related
Conditions, medicines and genes
Other ABO SNPs
- rs657152A;AA few different minor risk associations; see detailsWorth knowing
- rs1008708453A;AO2 alleles (ABO Type O) may be presentWorth knowing
- rs2519093C;Ccommon/normalTypical
- rs7853989C;CLikely blood group BTypical
- rs8176719-;-likely to be of blood type OTypical
- rs8176740A;ANo summary available.Typical
- rs8176743C;CNo summary available.Typical
- rs8176746T;TType B blood group (of ABO system)Typical
Notes
From SNPedia
Notes
23andMe blog each copy rs505922(C) is associated with 1.2x risk of pancreatic cancer influences ABO blood group
C;C
2.4x risk of pancreatic cancer, also increased risk of venous thromboembolism. This variation also determines your ABO Blood type status as not being blood type O.
Source and license
Adapted from rs505922 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.